Engineering metabolism for fuel, chemical, and pharmaceutical production
Advancements in our knowledge and understanding of biology, coupled with the emergence of fields such as synthetic biology and metabolic engineering have led to an unprecedented ability to harness cellular metabolism. However, the full potential of biological systems remains unrealized due to critical limitations in our ability to engineer and control them. The Metabolic Engineering and Biomanufacturing Laboratory seeks to overcome these limitations by designing and implementing transformational metabolic engineering and synthetic biology approaches to engineer biological systems. Combined with advancement of our fundamental knowledge of cellular metabolism, these approaches exploit the power and diversity of biology for the development of novel technologies across a range of applications. With a focus on the biomanufacturing of small molecules, this has enabled us to engineer cellular metabolism for the production of fuel, chemical, and pharmaceutical compounds from cost-effective and sustainable feedstocks.